Z01 CP010120-02042 (Z01) | |||
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Title | Biochemical markers in butadiene exposed workers | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | N/A | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $2,017 | Project Dates | N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (50.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The objectives of this study are to describe the distribution of butadiene metabolites in butadiene-exposed workers, to determine the relationship between butadiene exposure and the development of intermediate markers, to include metabolites, chromosomal abnormalities, SCEs, micronuclei, glycophorin A mutation, genetic mutations, adducts, macrocytic anemia, and possibly other markers. Further, attempts will be made to relate the level of butadiene exposure to the extent of intermediate marker response. Butadiene exposed subjects will be selected to represent a broad range of exposures, all greater than 10 ppm. Butadiene exposure will be established by environmental monitoring. Urine will be collected during exposure. Blood will be collected from a small group during exposure. Air butadiene exposure will also take place. Subsequently, a blood sample will be drawn and a phenotyping procedure with chlorzoxazone will be carried out, to assess P4502E1 phenotype activity. |